Insulin Glargine + Lixisenatide

100 units/mL + 33 mcg/mL Solution for Injection in Pre-filled Pen

? Indications

Insulin Glargine + Lixisenatide is used to improve blood sugar control in adults with type 2 diabetes.
It contains two active substances that help control your blood sugar:

• Insulin Glargine – A long-acting insulin that helps lower blood sugar levels.
• Lixisenatide – A GLP-1 receptor agonist that helps your body produce more insulin during meals and reduces the amount of sugar your body produces.

This medication is used with oral diabetes medications (e.g., metformin, pioglitazone, sulfonylureas) when these drugs alone or with other GLP-1 treatments or basal insulin are not sufficient to control blood sugar.

? Contraindications

Do not use Insulin Glargine + Lixisenatide if you:

• Are allergic to Insulin Glargine, Lixisenatide, or any of the other ingredients in this medication.

⚠ Warnings and Precautions

Talk to your doctor before using Insulin Glargine + Lixisenatide if you:

• Are using other diabetes medications.
• Have type 1 diabetes or diabetic ketoacidosis (a condition where acids build up in your blood).
• Are under 18 years of age.
• Have inflammatory bowel disease or delayed gastric emptying.
• Have or have ever had a thyroid disease.
• Experience severe abdominal pain that doesn't go away, which could be a sign of pancreatitis.
• Have or are at risk of dehydration (such as feeling unwell with nausea, vomiting, or diarrhea).

? Dosage and Administration

• Insulin Glargine + Lixisenatide is injected subcutaneously (under the skin), not in a vein or muscle.
• The best injection sites are the front thighs, upper arms, or abdomen.
• Always rotate the injection sites within the chosen area to reduce the risk of lumps or skin irritation.
• Use a new needle for each injection. Reusing needles may cause blockage and inaccurate doses. Safely dispose of the needle after use.

⚠ Drug Interactions

Inform your doctor if you are taking or have recently taken, or may take any other medications, including over-the-counter drugs, especially those for:

• Contraception.
• Pain.
• Hormonal treatments.
• Diabetes.
• High blood pressure.
• Asthma.
• Depression.
• Autoimmune diseases.
• Infections.

? Potential Side Effects

• The most common side effects include nausea, vomiting, and low blood sugar.
• Serious side effects may include severe allergic reactions, pancreatitis, and kidney problems.
• Infections at the injection site are also possible.

? Storage Instructions

• Keep this medicine out of the sight and reach of children.
• Do not use this medication after the expiry date shown on the pen and carton.
• Before opening: Store in the refrigerator (2°C - 8°C). Do not freeze.
• After opening: You may carry Insulin Glargine + Lixisenatide with you and store it at room temperature (not above 30°C) or in the refrigerator (2°C - 8°C) for up to 21 days. Discard after 21 days.
• Always replace the pen cap when not in use to protect it from light.
• Do not dispose of medications in sewage systems or household waste.