Repaglinide

Oral Antidiabetic Medication

? Indications

Repaglinide helps the pancreas produce more insulin, thereby lowering blood sugar (glucose) levels. It is primarily used in the treatment of Type 2 Diabetes.

? Contraindications

Do not use Repaglinide if you:

• Are allergic to Repaglinide or any of its ingredients.
• Have Type 1 Diabetes.
• Have Diabetic Ketoacidosis (high acidity in the body).
• Have severe liver disease.
• Are taking Gemfibrozil (a drug used to lower high blood fat levels).

⚠ Warnings and Precautions

Talk to your doctor before taking Repaglinide if:

• You have liver problems. It is not recommended for patients with moderate liver disease.
• You have kidney problems. Repaglinide should be taken with caution.
• You are about to undergo major surgery or have recently been ill.
• You are under 18 years of age or over 75 years of age.
  Repaglinide is not recommended for these age groups.

? Possible Side Effects

• Hypoglycemia (low blood sugar): Hypoglycemia can be mild or moderate but may occasionally develop into loss of consciousness or coma.
  If this happens, seek immediate medical help.
• Allergic reactions: Symptoms may include swelling, difficulty breathing, rapid heartbeat, dizziness, and sweating.
  Contact your doctor immediately if this occurs.
• Other side effects:
  • Stomach pain
  • Diarrhea
  • Acute coronary syndrome (though this may not be caused by the medication).

? Other Medications and Repaglinide

Do not take Repaglinide with Gemfibrozil.
Your response to Repaglinide may change if you are taking other medications, especially the following:

• Monoamine oxidase inhibitors (MAOIs) (used to treat depression)
• Beta-blockers (used for high blood pressure or heart conditions)
• Angiotensin-converting enzyme inhibitors (used for heart conditions)
• Salicylates (e.g., aspirin)
• Octreotide (used for cancer treatment)
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Steroids
• Oral contraceptives
• Thiazide diuretics ("water pills")
• Danazol
• Thyroid products
• Sympathomimetics (used for asthma)
• Antibiotics such as Clarithromycin
• Antifungal medications like Itraconazole
• Cyclosporine
• Deferasirox
• Antiepileptic drugs like Phenytoin
• St. John’s Wort
• Clopidogrel (blood thinner).

? How to Take Repaglinide

• Always take this medicine exactly as your doctor has told you.
• Your doctor will determine your dose.
• The usual starting dose is 0.5 mg before each main meal.
• Swallow the tablets with a glass of water, directly before or up to 30 minutes before each main meal.
• The dose can be adjusted by your doctor to a maximum of 4 mg to be taken immediately before or up to 30 minutes before each main meal.
• The maximum recommended daily dose is 16 mg.
• Do not take more Repaglinide than your doctor recommends.

? How to Store Repaglinide

• Keep Repaglinide out of the sight and reach of children.
• Do not use the medicine after the expiration date printed on the outer carton and blister pack after "EXP".
• This product does not require any special storage precautions.