Janumet XR Tablets

50 mg / 500 mg, 50 mg / 1000 mg, 100 mg / 1000 mg
Sitagliptin and Metformin Hydrochloride

⚠ This medication has been prescribed for you. Do not share it with others, as it may harm them even if they have similar symptoms.

? Indications for Use

Janumet XR is a prescription tablet containing two active ingredients: Sitagliptin phosphate (a DPP-4 inhibitor) and Metformin hydrochloride (a biguanide). These two work together to control blood sugar levels in patients with Type 2 diabetes mellitus (T2DM).

Your doctor prescribed Janumet XR to help lower your high blood sugar levels when diet and exercise alone are not sufficient. It improves post-meal insulin levels and reduces sugar production by the liver, helping your body respond better to insulin.

? Contraindications

Do not take Janumet XR if you:

• Are allergic to any of the active or inactive ingredients.
• Have Type 1 diabetes or diabetic ketoacidosis (increased ketones in blood or urine).
• Have severe kidney impairment.

Avoid Janumet XR if you have conditions that may worsen kidney function, such as:

• Certain heart diseases or serious infections (e.g., fever, diarrhea, or vomiting causing dehydration).
• Undergoing X-ray procedures with contrast dyes.

Consult your doctor about when to stop and resume Janumet XR under these conditions.

⚠ Warnings and Precautions

Tell your doctor if you have:

• Kidney or liver disease.
• Heart problems, including congestive heart failure.
• Heavy alcohol consumption (regular or binge drinking).
• Pregnancy or plans to become pregnant.
• Breastfeeding.
• Any condition causing dehydration (severe vomiting, diarrhea, or fever).

? Pancreatitis Risk: Cases of pancreatitis (inflammation of the pancreas) have been reported. Stop Janumet XR and seek medical attention if you experience severe, persistent stomach pain (with or without vomiting).

? Serious Skin Reactions: Some patients may develop bullous pemphigoid (severe skin reaction) requiring hospitalization. Consult your doctor if you notice blisters or skin peeling.

⚠ Use in Children and Elderly

• Not recommended for patients under 18 years.
• Elderly patients should take Janumet XR under regular medical supervision.

? Dosage and Administration

• Take Janumet XR once daily with the evening meal to reduce stomach upset.
• Swallow tablets whole (do not crush, cut, or chew).
• If you see a tablet-like substance in your stool, inform your doctor.
• Do not stop taking Janumet XR without consulting your doctor.

⚠ Missed Dose:

• Take it as soon as you remember.
• If it is almost time for your next dose, skip the missed dose. Do not double the dose.

⚠ Overdose:

• Contact your doctor immediately if you take more than the prescribed dose.

? Potential Side Effects

Serious Side Effects (Seek Immediate Medical Attention)

? Lactic Acidosis (Rare but Life-Threatening)
Symptoms include:

• Severe weakness, unusual muscle pain, difficulty breathing, nausea, vomiting, or dizziness.
• Cold sensation in limbs, slow/irregular heartbeat, sudden health deterioration.

Risk factors include:

• Severe kidney or liver disease.
• Heart failure requiring medication.
• Heavy alcohol consumption.
• Severe dehydration or undergoing surgery/X-ray procedures.

Common Side Effects

• Headache
• Hypoglycemia (low blood sugar)
• Gastrointestinal issues (diarrhea, nausea, bloating, vomiting, metallic taste, stomach pain)
• Upper respiratory infections (sore throat, nasal congestion)

Other Reported Side Effects

• Skin reactions (rash, hives, swelling of face/lips/tongue, difficulty breathing).
• Joint and muscle pain.
• Kidney problems (sometimes requiring dialysis).
• Blistering skin reactions.

? If you experience severe allergic reactions or pancreatitis symptoms, stop taking Janumet XR and consult your doctor immediately.