Glacera XR - Product Description

? This medication contains metformin and is used as an oral antidiabetic agent for the management of Type 2 diabetes mellitus. It helps control blood sugar (glucose) levels and improves the body's ability to use insulin effectively. It is often combined with dietary changes and physical activity. This medication may also be used for other purposes; consult your healthcare provider or pharmacist if you have questions.

? Dosage and Administration

? There is no fixed dosing regimen for controlling high blood sugar in Type 2 diabetic patients on Glacera XR. The dosage should be individualized based on both efficacy and tolerance, without exceeding the recommended maximum daily doses.

? The maximum recommended daily dose for adults is 2000 mg. Glacera XR is generally administered once a day with the evening meal.

? The dosage of Glacera XR should start low, with gradual titration to minimize gastrointestinal side effects and allow determination of the minimum effective dose to control blood sugar levels.

• Adults:
  • Starting dose: The usual starting dose for Glacera XR tablets (metformin hydrochloride extended-release) is 500 mg once daily with the evening meal.
  • Dose escalation: Increase the dose by 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal.
  • If blood sugar control is not achieved with 2000 mg once daily, consideration should be given to trying 1000 mg twice daily.
  • If higher doses of metformin are required, Glacera XR can be used with a maximum total daily dose of 2550 mg in divided doses, as indicated above.

⚠ Warnings and Precautions

? Risk of Lactic Acidosis: Metformin hydrochloride may cause rare but serious side effects called lactic acidosis, especially if kidney function is impaired, or if you have uncontrolled diabetes, serious infections, liver problems, or dehydration.

• Symptoms of Lactic Acidosis:
  • Vomiting
  • Abdominal pain
  • Muscle cramps
  • General discomfort with severe fatigue
  • Difficulty breathing
  • Low body temperature and heart rate

? Risk of Hypoglycemia: If you are taking metformin with other antidiabetic medications, it may lead to low blood sugar levels.

• Symptoms of Hypoglycemia:
  • Weakness
  • Dizziness
  • Excessive sweating
  • Rapid heartbeat
  • Vision disturbances or difficulty concentrating
  • Eating or drinking something containing sugar usually helps.

? Contraindications

? If you have kidney problems, or acute or chronic metabolic acidosis such as diabetic ketoacidosis.

? Excessive alcohol consumption may increase the risk of lactic acidosis.

? Storage Instructions

? Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children.

? Ingredients

Available in various concentrations from different manufacturers:

• 500 mg: Each extended-release tablet contains 500 mg of metformin hydrochloride, equivalent to 390 mg of metformin base.
• 750 mg: Each extended-release tablet contains 750 mg of metformin hydrochloride, equivalent to 585 mg of metformin base.
• 1000 mg: Each extended-release tablet contains 1000 mg of metformin hydrochloride, equivalent to