Pioglitazone / Glimepiride for Oral Use

What is Pioglitazone / Glimepiride and what is it used for?
? Pioglitazone and Glimepiride are oral medications used to help control blood sugar levels in people with type 2 diabetes.
? Used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Do not take Pioglitazone / Glimepiride
❌ If you are allergic to pioglitazone, glimepiride, sulfa drugs, or any other ingredients in this medication.
❌ If you have severe or advanced heart failure.
❌ If you have active bladder cancer.
❌ If you have diabetic ketoacidosis.

Warnings and precautions
? Consult your doctor or pharmacist if you have:

• A history of heart failure or heart disease.
• Fluid retention.
• Bladder cancer.
• Liver or kidney disease.
• A genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency.
• Diabetic eye problems.
• A history of heart attack or stroke.

Possible side effects of Pioglitazone / Glimepiride
⚠️ Common side effects include:

• Hypoglycemia (low blood sugar).
• Weight gain.
• Headache.
• Muscle pain.
• Anxiety.
• Depression.
• Rapid heart rate.
• Nausea and diarrhea.
• Cold symptoms like nasal congestion, sinus pain, sneezing, and sore throat.

Other medications and Pioglitazone / Glimepiride
? Pioglitazone / Glimepiride may interact with other medications, affecting their effectiveness. Notable interactions include:

• Insulin: May increase the risk of heart disease when combined with insulin.
• Strong CYP2C8 inhibitors: Can significantly increase pioglitazone exposure.
• Colesevelam: Can reduce the maximum plasma concentration of glimepiride.
• Oral miconazole.
• Drugs increasing CYP2C8 or CYP2C9 activity, like rifampin.

How to take Pioglitazone / Glimepiride
? Typical adult dose for type 2 diabetes:

• Initial dose: Pioglitazone 30 mg / Glimepiride 2 mg or Pioglitazone 30 mg / Glimepiride 4 mg, taken orally once a day.
• Maintenance dose: Adjust gradually based on treatment response and tolerance.
• Take with the first meal of the day.

How to store Pioglitazone / Glimepiride
? Storage instructions:

• Store at room temperature, away from moisture, heat, and light.
• Keep the bottle tightly closed when not in use.
• Store between 59°F to 86°F (15°C to 30°C).
• Keep in the original container to protect from light.